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ATTENTION: The purpose of this website is to produce hypotheses that can explain the causes of possible diseases based on the cause of alopecia, which is addressed with a multidisciplinary and non-traditional approach.
This is not an approved method or hypothesis. It is not a recommendation. It is not suitable for personal action and is not designed for personal action. Do not make any assumptions or applications without consulting health professionals. No responsibility is assumed.
The Prevailing Paradigm vs. The Human Topological Hypothesis
The Prevailing Paradigm vs. The Human Topological Hypothesis
Mechanical stress does not mean that a tissue is completely pulled to one side. The mechanical stress mentioned here is a chaotic mechanical stress that can change the morphology of the skin over time with micro-folds and folds and cause some damage.
According to the prevailing paradigm:
According to the prevailing paradigm:
According to the Human Topological Hypothesis:
The body's immune system mistakenly attacks its own cells and tissues, causing damage [11].
If the immune system receives aberrant signaling, then immune activation occurs.
If the immune system behaves aberrantly and exhibits self-reactivity, then certain autoimmune or idiopathic diseases may develop.
Thus, it is generally assumed that an unexplained anomaly in the immune system — potentially due to a genetic disorder, mutation, or similar factors — may lead to the development of various autoimmune diseases.
According to the Human Topological Hypothesis, mechanical stress arising from topological knots within the skin—exacerbated by the influence of hair shafts—remains invisible to direct observation. When the skin is not evaluated as an integrated system, this hidden mechanical stress may be misinterpreted as a primary autoimmune disorder.
If the skin exhibits limited analytic continuity and restricted extensibility, and if follicular stiffness and vectorial sensitivity are present, then regional topological shifts may arise, resulting in mechanical stress that could lead to certain undiagnosed or autoimmune diseases.
If topological deformation is excessive and mechanical stress becomes chronic, then loss of tissue equilibrium may occur, potentially leading to regional oncogenesis.
Current research confirms that mechanical stresses are transmitted through tissue networks via cellular connections, with localized forces affecting distant regions due to the limited analytic continuity of biological tissues ([8],[9] ,[10]).
This validates the mechanical stress transmission principle underlying the Human Topological Hypothesis.
[8] Chanet, S., & Martin, A. C. (2014). Mechanical force sensing in tissues. Progress in Molecular Biology and Translational Science, 126, 317-352. https://doi.org/10.1016/B978-0-12-394624-9.00013-0
[9] Fabry, B., Maksym, G. N., Butler, J. P., Glogauer, M., Navajas, D., Taback, N. A., Millet, E. J., & Fredberg, J. J. (2008). Slow stress propagation in adherent cells. Biophysical Journal, 95(7), 3470-3478. https://pmc.ncbi.nlm.nih.gov/articles/PMC2599816/
[10] Swaminathan, V., & Gloerich, M. (2021). Decoding mechanical cues by molecular mechanotransduction. Current Opinion in Cell Biology, 72, 72-83. https://doi.org/10.1016/j.ceb.2021.05.006
[11] Wikipedia contributors. (2025, May 24). Autoimmune disease. In Wikipedia, The Free Encyclopedia. Retrieved 21:36, June 5, 2025, from https://en.wikipedia.org/w/index.php?title=Autoimmune_disease&oldid=1291946753
Abberant Signaling = Signal of God ?
Where there is no scientific explanation, there is often divine power.
“This is an ironic illustration that humorously highlights the tendency to resort to supernatural explanations when scientific understanding is lacking.”
Abberant Signaling = Mechanical Stress ?
In contrast, here mechanical stress is not a gap-filler, but a testable, observable cause supported by evidence.
“This illustration highlights how previous gaps in understanding were filled with supernatural explanations, but today, mechanical stress offers a concrete, evidence-based mechanism — not just another mystery.”
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